PREPRINTS
Hosseini A, Lindholm HT, Chen R, Mehdipour P, Marhon SA, Ishak CA, De Carvalho DD. Retroelement decay by the exonuclease XRN1 is a viral mimicry dependency in cancer. bioRxiv 2023
Viner C, Ishak CA, Johnson J, Walker NJ, Shi H, Sjöberg-Herrera HK, Shen SY, Lardo SM, Adams DJ, Ferguson-Smith AC, De Carvalho DD, Hainer SJ, Bailey TL, Hoffman MM. Modeling methyl-sensitive transcription factor motifs with an expanded epigenetic alphabet. bioRxiv 2023
Viner C, Ishak CA, Johnson J, Walker NJ, Shi H, Sjöberg-Herrera HK, Shen SY, Lardo SM, Adams DJ, Ferguson-Smith AC, De Carvalho DD, Hainer SJ, Bailey TL, Hoffman MM. Modeling methyl-sensitive transcription factor motifs with an expanded epigenetic alphabet. bioRxiv 2023
PUBLICATIONS
Endogenous Retroelements and the Viral Mimicry Response in Cancer Therapy and Cellular Homeostasis.
Chen R*, Ishak CA*, De Carvalho DD.
Cancer Discov. 2021 Nov
DNA hypomethylating agents increase activation and cytolytic activity of CD8+ T cells.
Loo Yau H, Bell E, Ettayebi I, de Almeida FC, Boukhaled GM, Shen SY, Allard D, Morancho B, Marhon SA, Ishak CA, Gonzaga IM, da Silva Medina T, Singhania R, Chakravarthy A, Chen R, Mehdipour P, Pommey S, Klein C, Amarante-Mendes GP, Roulois D, Arribas J, Stagg J, Brooks DG, De Carvalho DD.
Mol Cell. 2021 Apr
Spliceosome-Targeted Therapies Induce dsRNA Responses.
Ishak CA*, Loo Yau H*, De Carvalho DD.
Immunity. 2021 Jan
Epigenetic therapy induces transcription of inverted SINEs and ADAR1 dependency.
Mehdipour P, Marhon SA, Ettayebi I, Chakravarthy A, Hosseini A, Wang Y, de Castro FA, Loo Yau H, Ishak C, Abelson S, O'Brien CA, De Carvalho DD.
Nature. 2020 Dec
DNA Methylation Profiling of Premalignant Lesions as a Path to Ovarian Cancer Early Detection.
Ishak CA, De Carvalho DD.
Clin Cancer Res. 2020 Dec
Haploinsufficiency of RREB1 causes a Noonan-like RASopathy via epigenetic reprogramming of RAS-MAPK pathway genes.
Kent OA, Saha M, Coyaud E, Burston HE, Law N, Dadson K, Chen S, Laurent EM, St-Germain J, Sun RX, Matsumoto Y, Cowen J, Montgomery-Song A, Brown KR, Ishak C, Rose J, De Carvalho DD, He HH, Raught B, Billia F, Kannu P, Rottapel R.
Nat Commun. 2020 Sep
Reactivation of Endogenous Retroelements in Cancer Development and Therapy
Ishak CA, De Carvalho DD.
Annual Review of Cancer Biology. 2020 Mar
An open-label, phase II multicohort study of an oral hypomethylating agent CC-486 and durvalumab in advanced solid tumors.
Taylor K, Loo Yau H, Chakravarthy A, Wang B, Shen SY, Ettayebi I, Ishak CA, Bedard PL, Abdul Razak A, R Hansen A, Spreafico A, Cescon D, Butler MO, Oza AM, Lheureux S, Stjepanovic N, Van As B, Boross-Harmer S, Wang L, Pugh TJ, Ohashi PS, Siu LL, De Carvalho DD.
J Immunother Cancer. 2020 Aug
An RB-Condensin II Complex Mediates Long-Range Chromosome Interactions and Influences Expression at Divergently Paired Genes.
Marshall AE, Ishak CA, Dick FA.
Mol Cell Biol. 2020 Jan
DNA Methylation as a Robust Classifier of Epithelial Ovarian Cancer.
Ishak CA, Lheureux S, De Carvalho DD.
Clin Cancer Res. 2019 Oct
Deregulation of Retroelements as an Emerging Therapeutic Opportunity in Cancer.
Ishak CA, Classon M, De Carvalho DD.
Trends Cancer. 2018 Aug
Immunohistochemical Detection of the Retinoblastoma Protein.
Ishak CA, Cecchini MJ, Howlett CJ, Dick FA.
Methods Mol Biol. 2018
Disruption of CDK-resistant chromatin association by pRB causes DNA damage, mitotic errors, and reduces Condensin II recruitment.
Ishak CA, Coschi CH, Roes MV, Dick FA.
Cell Cycle. 2017 Aug
An RB-EZH2 Complex Mediates Silencing of Repetitive DNA Sequences.
Ishak CA, Marshall AE, Passos DT, White CR, Kim SJ, Cecchini MJ, Ferwati S, MacDonald WA, Howlett CJ, Welch ID, Rubin SM, Mann MRW, Dick FA.
Mol Cell. 2016 Dec
Loss of the retinoblastoma tumor suppressor correlates with improved outcome in patients with lung adenocarcinoma treated with surgery and chemotherapy.
Cecchini MJ, Ishak CA, Passos DT, Warner A, Palma DA, Howlett CJ, Driman DK, Dick FA.
Hum Pathol. 2015 Dec
Conditional haploinsufficiency of the retinoblastoma tumor suppressor gene.
Ishak CA, Dick FA.
Mol Cell Oncol. 2014 Oct
Haploinsufficiency of an RB-E2F1-Condensin II complex leads to aberrant replication and aneuploidy.
Coschi CH, Ishak CA, Gallo D, Marshall A, Talluri S, Wang J, Cecchini MJ, Martens AL, Percy V, Welch I, Boutros PC, Brown GW, Dick FA.
Cancer Discov. 2014 Jul
Loss of the mammalian DREAM complex deregulates chondrocyte proliferation.
Forristal C, Henley SA, MacDonald JI, Bush JR, Ort C, Passos DT, Talluri S, Ishak CA, Thwaites MJ, Norley CJ, Litovchick L, DeCaprio JA, DiMattia G, Holdsworth DW, Beier F, Dick FA.
Mol Cell Biol. 2014 Jun
Chen R*, Ishak CA*, De Carvalho DD.
Cancer Discov. 2021 Nov
DNA hypomethylating agents increase activation and cytolytic activity of CD8+ T cells.
Loo Yau H, Bell E, Ettayebi I, de Almeida FC, Boukhaled GM, Shen SY, Allard D, Morancho B, Marhon SA, Ishak CA, Gonzaga IM, da Silva Medina T, Singhania R, Chakravarthy A, Chen R, Mehdipour P, Pommey S, Klein C, Amarante-Mendes GP, Roulois D, Arribas J, Stagg J, Brooks DG, De Carvalho DD.
Mol Cell. 2021 Apr
Spliceosome-Targeted Therapies Induce dsRNA Responses.
Ishak CA*, Loo Yau H*, De Carvalho DD.
Immunity. 2021 Jan
Epigenetic therapy induces transcription of inverted SINEs and ADAR1 dependency.
Mehdipour P, Marhon SA, Ettayebi I, Chakravarthy A, Hosseini A, Wang Y, de Castro FA, Loo Yau H, Ishak C, Abelson S, O'Brien CA, De Carvalho DD.
Nature. 2020 Dec
DNA Methylation Profiling of Premalignant Lesions as a Path to Ovarian Cancer Early Detection.
Ishak CA, De Carvalho DD.
Clin Cancer Res. 2020 Dec
Haploinsufficiency of RREB1 causes a Noonan-like RASopathy via epigenetic reprogramming of RAS-MAPK pathway genes.
Kent OA, Saha M, Coyaud E, Burston HE, Law N, Dadson K, Chen S, Laurent EM, St-Germain J, Sun RX, Matsumoto Y, Cowen J, Montgomery-Song A, Brown KR, Ishak C, Rose J, De Carvalho DD, He HH, Raught B, Billia F, Kannu P, Rottapel R.
Nat Commun. 2020 Sep
Reactivation of Endogenous Retroelements in Cancer Development and Therapy
Ishak CA, De Carvalho DD.
Annual Review of Cancer Biology. 2020 Mar
An open-label, phase II multicohort study of an oral hypomethylating agent CC-486 and durvalumab in advanced solid tumors.
Taylor K, Loo Yau H, Chakravarthy A, Wang B, Shen SY, Ettayebi I, Ishak CA, Bedard PL, Abdul Razak A, R Hansen A, Spreafico A, Cescon D, Butler MO, Oza AM, Lheureux S, Stjepanovic N, Van As B, Boross-Harmer S, Wang L, Pugh TJ, Ohashi PS, Siu LL, De Carvalho DD.
J Immunother Cancer. 2020 Aug
An RB-Condensin II Complex Mediates Long-Range Chromosome Interactions and Influences Expression at Divergently Paired Genes.
Marshall AE, Ishak CA, Dick FA.
Mol Cell Biol. 2020 Jan
DNA Methylation as a Robust Classifier of Epithelial Ovarian Cancer.
Ishak CA, Lheureux S, De Carvalho DD.
Clin Cancer Res. 2019 Oct
Deregulation of Retroelements as an Emerging Therapeutic Opportunity in Cancer.
Ishak CA, Classon M, De Carvalho DD.
Trends Cancer. 2018 Aug
Immunohistochemical Detection of the Retinoblastoma Protein.
Ishak CA, Cecchini MJ, Howlett CJ, Dick FA.
Methods Mol Biol. 2018
Disruption of CDK-resistant chromatin association by pRB causes DNA damage, mitotic errors, and reduces Condensin II recruitment.
Ishak CA, Coschi CH, Roes MV, Dick FA.
Cell Cycle. 2017 Aug
An RB-EZH2 Complex Mediates Silencing of Repetitive DNA Sequences.
Ishak CA, Marshall AE, Passos DT, White CR, Kim SJ, Cecchini MJ, Ferwati S, MacDonald WA, Howlett CJ, Welch ID, Rubin SM, Mann MRW, Dick FA.
Mol Cell. 2016 Dec
Loss of the retinoblastoma tumor suppressor correlates with improved outcome in patients with lung adenocarcinoma treated with surgery and chemotherapy.
Cecchini MJ, Ishak CA, Passos DT, Warner A, Palma DA, Howlett CJ, Driman DK, Dick FA.
Hum Pathol. 2015 Dec
Conditional haploinsufficiency of the retinoblastoma tumor suppressor gene.
Ishak CA, Dick FA.
Mol Cell Oncol. 2014 Oct
Haploinsufficiency of an RB-E2F1-Condensin II complex leads to aberrant replication and aneuploidy.
Coschi CH, Ishak CA, Gallo D, Marshall A, Talluri S, Wang J, Cecchini MJ, Martens AL, Percy V, Welch I, Boutros PC, Brown GW, Dick FA.
Cancer Discov. 2014 Jul
Loss of the mammalian DREAM complex deregulates chondrocyte proliferation.
Forristal C, Henley SA, MacDonald JI, Bush JR, Ort C, Passos DT, Talluri S, Ishak CA, Thwaites MJ, Norley CJ, Litovchick L, DeCaprio JA, DiMattia G, Holdsworth DW, Beier F, Dick FA.
Mol Cell Biol. 2014 Jun
